Rapid identification of proteins by peptide-mass fingerprinting.

  title={Rapid identification of proteins by peptide-mass fingerprinting.},
  author={Darryl J.C. Pappin and Peter Hojrup and Alan J. Bleasby},
  journal={Current biology : CB},
  volume={3 6},
BACKGROUND Developments in 'soft' ionisation techniques have revolutionized mass-spectro-metric approaches for the analysis of protein structure. For more than a decade, such techniques have been used, in conjuction with digestion b specific proteases, to produce accurate peptide molecular weight 'fingerprints' of proteins. These fingerprints have commonly been used to screen known proteins, in order to detect errors of translation, to characterize post-translational modifications and to assign… CONTINUE READING
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