Rapid identification of patients with essential hypertension sensitive to acebutolol (a new cardioselective beta-blocker).

@article{Mnard1976RapidIO,
  title={Rapid identification of patients with essential hypertension sensitive to acebutolol (a new cardioselective beta-blocker).},
  author={Jo{\"e}l M{\'e}nard and Xavier Y. Bertagna and P N'guyen and Patrice Degoulet and Pierre Corvol},
  journal={The American journal of medicine},
  year={1976},
  volume={60 6},
  pages={
          886-90
        }
}
Acebutolol, a new cardioselective beta-blocking agent, was administered for 48 hours to 44 patients with essential hypertension at a total dosage of 2.0 g (2,000 mg). The slowing down of their pulse rate and the decrease in blood pressure were highly significant, whereas eight subjects treated with placebos had no change in either the pulse rate or blood pressure. Plasma renin activity decreased from 2.26 +/- 2.11 ng/ml/hour to 0.87 +/- 1.04 ng/ml/hour. The decrease in blood pressure was… Expand
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  • I. Franz
  • Medicine
  • The American journal of cardiology
  • 1980
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The data indicate that acebutolol is effective in diuretic‐resistant hypertensive patients and that indices of the renin‐angiotensin system are not predictors of the therapeutic response. Expand
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TLDR
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TLDR
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TLDR
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