Rapid high resolution single nucleotide polymorphism-comparative genome hybridization mapping in Caenorhabditis elegans.

@article{Flibotte2009RapidHR,
  title={Rapid high resolution single nucleotide polymorphism-comparative genome hybridization mapping in Caenorhabditis elegans.},
  author={Stephane Flibotte and Mark L Edgley and Jason S. Maydan and Jon Taylor and Rick Zapf and Robert H. Waterston and Donald G. Moerman},
  journal={Genetics},
  year={2009},
  volume={181 1},
  pages={33-7}
}
We have developed a significantly improved and simplified method for high-resolution mapping of phenotypic traits in Caenorhabditis elegans using a combination of single nucleotide polymorphisms (SNPs) and oligo array comparative genome hybridization (array CGH). We designed a custom oligonucleotide array using a subset of confirmed SNPs between the canonical wild-type Bristol strain N2 and the Hawaiian isolate CB4856, populated with densely overlapping 50-mer probes corresponding to both N2… CONTINUE READING
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Whole-genome sequencing and variant discovery in C. elegans

  • L W Hillier, G T Marth, A R Quinlin, D Dooling, G Fewell
  • Nat. Methods
  • 2008
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