• Corpus ID: 23941231

Rapid high-performance liquid chromatography method for determination of pregabalin in a pharmaceutical dosage form following derivatization with fluorescamine.

@article{Martinc2010RapidHL,
  title={Rapid high-performance liquid chromatography method for determination of pregabalin in a pharmaceutical dosage form following derivatization with fluorescamine.},
  author={Bo{\vs}tjan Martinc and Iztok Grabnar and Ale{\vs} Mrhar and Toma{\vz} Vovk},
  journal={Journal of AOAC International},
  year={2010},
  volume={93 4},
  pages={
          1069-76
        }
}
A simple, fast, and sensitive HPLC method was developed and validated for the evaluation of pregabalin in a pharmaceutical dosage form using fluorescamine as a derivatization agent for the first time. After a precolumn derivatization (5 min, room temperature), the reaction mixture was chromatographed on a C18 column with isocratic elution using 0.2% of triethylamine in a mixture of methanol and water (10 + 90, v/v). 3-Aminopentanoic acid was used as the internal standard. Using fluorescent… 
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