Rapid heterozygote detection in Glanzmann's thrombasthenia.

@article{Sharp1998RapidHD,
  title={Rapid heterozygote detection in Glanzmann's thrombasthenia.},
  author={W J Sharp and Uma Khanduri and Brian Sidney Christie},
  journal={British journal of haematology},
  year={1998},
  volume={101 1},
  pages={66-9}
}
To assess the potential of using flow cytometric analysis of platelet glycoprotein IIb in the detection of heterozygotes in Glanzmann's thrombasthenia (GT) we compared the fluorescence intensity of anti-CD41-labelled platelets of obligatory heterozygotes with that of normal subjects. This study showed that normal subjects had relative fluorescences occasionally overlapping with heterozygotes. Use of an independent factor, the mean platelet volume, as a correction factor for platelet size… CONTINUE READING