Rapid hepatic cell attachment onto biodegradable polymer surfaces without toxicity using an avidin-biotin binding system.

@article{Kojima2006RapidHC,
  title={Rapid hepatic cell attachment onto biodegradable polymer surfaces without toxicity using an avidin-biotin binding system.},
  author={Nobuhiko Kojima and Tomoki Matsuo and Yasuyuki Sakai},
  journal={Biomaterials},
  year={2006},
  volume={27 28},
  pages={
          4904-10
        }
}
Efficient cell attachment to biodegradable polymer scaffolds is a necessary prerequisite in tissue engineering. However, it is difficult to evenly cover scaffold surfaces with cells because scaffolds are generally highly porous, with complex three-dimensional (3D) surfaces. In this article, we demonstrate the efficiency of avidin-biotin binding systems (ABBS) for the initial attachment of biotinylated Hep G2 cells to avidin adsorbed flat, two-dimensional (2D) and highly porous 3D poly L-lactic… CONTINUE READING
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