Rapid glia expression and release of proinflammatory cytokines in experimental Klebsiella pneumoniae meningoencephalitis.

@article{Wen2007RapidGE,
  title={Rapid glia expression and release of proinflammatory cytokines in experimental Klebsiella pneumoniae meningoencephalitis.},
  author={Li-li Wen and Chien-Tsai Chiu and Ya-Ni Huang and Che-feng Chang and Jia-yi Wang},
  journal={Experimental neurology},
  year={2007},
  volume={205 1},
  pages={
          270-8
        }
}
The host immune/inflammatory response following CNS infection by Klebsiella pneumoniae remains poorly understood. Using a rat model of K. pneumoniae meningoencephalitis, we investigated the temporal profiles of brain proinflammatory cytokines and their cellular sources. Leukocyte counts significantly increased in cerebrospinal fluid (CSF) at 2 h after K. pneumoniae inoculation into the rat brain but were still much lower than blood leukocyte counts. However, concentrations of tumor necrosis… CONTINUE READING

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