Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice.

@article{Beck1997RapidGE,
  title={Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice.},
  author={Melinda A. Beck},
  journal={Biomedical and environmental sciences : BES},
  year={1997},
  volume={10 2-3},
  pages={
          307-15
        }
}
  • Melinda A. Beck
  • Published 1997 in Biomedical and environmental sciences : BES
Keshan disease, an endemic cardiomyopathy in China, can be prevented with selenium (Se) supplementation. However, the seasonal and annual nature of the disease suggests that an infectious co-factor is required along with a deficiency in Se. Using a murine model of coxsackievirus B3 (CVB3)-induced myocarditis, Se-deficient mice were shown to be more susceptible to the cardiopathologic effects of the virus. In addition, a normal benign strain of CVB3 becomes virulent in Se-deficient mice. This… CONTINUE READING

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