Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy.

@article{Berger2010RapidGO,
  title={Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy.},
  author={Carole L. Berger and Kristin Hoffmann and Juan Gabriel Vasquez and Shrikant Mane and Julia C Lewis and Renata B. Filler and Aiping Lin and Hongyu Zhao and Tyler Durazzo and Abigail Baird and William S. Lin and Francine F Foss and Inger B Christensen and Michael Girardi and Robert E. Tigelaar and Richard Edelson},
  journal={Blood},
  year={2010},
  volume={116 23},
  pages={4838-47}
}
Extracorporeal photochemotherapy (ECP) is widely used to treat cutaneous T-cell lymphoma, graft-versus-host disease, and allografted organ rejection. Its clinical and experimental efficacy in cancer immunotherapy and autoreactive disorders suggests a novel mechanism. This study reveals that ECP induces a high percentage of processed monocytes to enter the antigen-presenting dendritic cell (DC) differentiation pathway, within a single day, without added cytokines, as determined by enhanced… CONTINUE READING

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