Rapid gas-liquid chromatographic determination of carbamazepine in plasma.

  title={Rapid gas-liquid chromatographic determination of carbamazepine in plasma.},
  author={R. Perchalski and B. Wilder},
  journal={Clinical chemistry},
  volume={20 4},
A rapid, sensitive method is described for the quantitative determination of carbamazepine in plasma. The coefficient of variation of replicate extractions is typically within 5%. This procedure can be completed in 45 min and the derivatives formed by the reaction of the drug and internal standard with dimethylformamide dimethyl acetal are stable for at least 17 h. The lower limit of detection is 0.2 µg/ml of plasma. 

Topics from this paper

Rapid and sensitive liquid chromatographic determination of carbamazepine suitable for use in monitoring multiple-drug anticonvulsant therapy.
A rapid, sensitive and selective method for the determination of carbamazepine and its major metabolite in plasma has been developed. Other commonly used anticonvulsants can be determined in the sameExpand
Determination of carbamazepine in blood or plasma by high-pressure liquid chromatography.
We described a sensitive and precise high-pressure liquid-chromatographic method in which 5-(p-methylphenyl)-5-phenylhydantoin is used as the internal standard in determining carbamazepine in wholeExpand
Gas--liquid chromatographic determination of carbamazepine and phenylethylmalonamide in plasma after reaction with dimethylformamide dimethylacetal.
A previously published procedure for the gas chromatographic analysis of carbamazepine has been modified and expanded to allow simultaneous determination of phenylethylmalonamide, a metabolite ofExpand
Analysis for carbamazepine in serum by electron-capture gas chromatography.
An analytical method for determining carbamazepine in serum by electron-capture gas chromatography with coefficients of variation routinely are less than 2% for concentrations of carbsepine that are within the therapeutic range. Expand
Determination of carbamazepine by HPLC electrochemical detection and application for estimation of imipramine desipramine, doxepin and nordoxepin.
The method is useful for the separation and quantitation of carbamazepine from imipramine and desipramines which is useful in cases where one of these drugs is given concurrently with carbamazenine. Expand
GLC determination of carbamazepine suitable for pharmacokinetic studies.
A GLC determination of carbamazepine in plasma and urine is described by injecting the cyano derivative, which is suitable for pharmacokinetic studies, since it is specific and accurate down to 0.27 mug/ml. Expand
A rapid spectrophotometric procedure for the simultaneous micro determination of carbamazepine and 5, 5-diphenyl-hydantoin in blood.
The combined method is rapid, reliable and has a detection threshold of less than 0.1 mg/100 ml for each drug. Expand
Determination of antiepileptic drugs.
Gas and liquid chromatographic methods for the determination of the most commonly monitored antiepileptic drugs are reviewed, including phenobarbital, phenytoin, carbamazepine, primidone, ethosuximide, valproic acid and clonazepam along with a new compound, progabide. Expand
Therapeutic monitoring of anticonvulsant drugs: gas-chromatographic simultaneous determination of primidone, phenylethylmalonamide, carbamazepine, and diphenylhydantoin.
We describe a sensitive and precise gas-chromatographic method in which benzylmalonate methylester monoamide is used as the internal standard for the simultaneous determination of primidone,Expand
An Ultra-sensitive LC Method for the Simultaneous Determination of Paracetamol, Carbamazepine, Losartan and Ciprofloxacin in Bulk Drug, Pharmaceutical Formulation and Human Serum by Programming the Detector
An ultra-sensitive LC method for the simultaneous quantitation of paracetamol, carbamazepine, losartan and ciprofloxacin have been developed and validated following the ICH guidelines at isobesticExpand