Rapid eye movement latency and mood following a delay of bedtime in healthy subjects: do the effects mimic changes in depressive illness?

@article{David1991RapidEM,
  title={Rapid eye movement latency and mood following a delay of bedtime in healthy subjects: do the effects mimic changes in depressive illness?},
  author={Michele M A David and Alistair Maclean and J. B. Knowles and M E Coulter},
  journal={Acta psychiatrica Scandinavica},
  year={1991},
  volume={84 1},
  pages={33-9}
}
The phase advance hypothesis proposes that a phase advance of certain circadian rhythms (such as rapid eye movement (REM) sleep propensity) relative to the sleep-wake cycle is implicated in the pathophysiology and pathogenesis of depression. In an earlier study, we reported that a 6-h delay of sleep in normals produced REM changes that resembled the… CONTINUE READING