Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium.

@article{Das2008RapidEA,
  title={Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium.},
  author={Shamik Das and Aniruddha Banerji and Eva Frei and Amitava Chatterjee},
  journal={Life sciences},
  year={2008},
  volume={82 9-10},
  pages={
          467-76
        }
}
Interactions between tumour cells and the extracellular matrix (ECM) strongly influence tumour development, affecting cell survival, proliferation and migration. Many of these interactions are mediated through a family of cell surface receptors named integrins. Fibronectin and its integrin receptors play important roles in tumour development. The alpha5beta 1 integrin interacts with the central cell adhesive region of fibronectin and requires both the RGD and synergy sites for maximal binding… CONTINUE READING

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