Rapid expansion of the Ly49 gene cluster in rat.

  title={Rapid expansion of the Ly49 gene cluster in rat.},
  author={Brian T. Wilhelm and Dixie L. Mager},
  volume={84 1},
The cytotoxic activity of mouse natural killer cells is regulated in part through cell surface molecules belonging to the Ly49 multigene family. In mice, the genomic sequence of the Ly49 gene cluster has been examined in detail and this analysis provided a model of the expansion of this multigene family. In the present study, we have analyzed a 1.8-Mb region of the draft rat genome revealing surprising differences in size and gene content between the mouse and the rat Ly49 clusters. The rat… CONTINUE READING

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