Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.

@article{Csaszar2012RapidEO,
  title={Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.},
  author={Elizabeth Csaszar and Daniel C. Kirouac and Mei Yu and Weijia Wang and Wenlian Qiao and Michael P. Cooke and Anthony E. Boitano and Caryn Y Ito and Peter W. Zandstra},
  journal={Cell stem cell},
  year={2012},
  volume={10 2},
  pages={218-29}
}
Clinical hematopoietic transplantation outcomes are strongly correlated with the numbers of cells infused. Anticipated novel therapeutic implementations of hematopoietic stem cells (HSCs) and their derivatives further increase interest in strategies to expand HSCs ex vivo. A fundamental limitation in all HSC-driven culture systems is the rapid generation of differentiating cells and their secreted inhibitory feedback signals. Herein we describe an integrated computational and experimental… CONTINUE READING
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