Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele.

@article{Papanicolaou2003RapidEO,
  title={Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele.},
  author={Genovefa Anna Papanicolaou and J Latouche and Cuiwen Tan and J. -M. Dupont and Jeffrey Stiles and Eric G. Pamer and Michel Sadelain},
  journal={Blood},
  year={2003},
  volume={102 7},
  pages={2498-505}
}
Cytomegalovirus (CMV) is a major threat in patients undergoing allogeneic bone marrow transplantation. The adoptive transfer of CMV-specific cytotoxic T lymphocytes (CTLs) expanded from the blood of CMV-seropositive donors has been shown to effectively control CMV infection. However, the requirement for safe and effective antigen-presenting cells (APCs) for each patient precludes broad applicability of this successful form of therapy. Here we analyze the ability of artificial APCs (AAPCs) to… CONTINUE READING

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