Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle.

  title={Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle.},
  author={Anila S Mathai and Arend Bonen and Carley R. Benton and Deborah L Robinson and Terry E. Graham},
  journal={Journal of applied physiology},
  volume={105 4},
The mRNA of the nuclear coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) increases during prolonged exercise and is influenced by carbohydrate availability. It is unknown if the increases in mRNA reflect the PGC-1alpha protein or if glycogen stores are an important regulator. Seven male subjects [23 +/- 1.3 yr old, maximum oxygen uptake (Vo(2 max)) 48.4 +/- 0.8 ml.kg(-1).min(-1)] exercised to exhaustion ( approximately 2 h) at 65% Vo(2 max) followed… CONTINUE READING
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