Rapid evolutionary escape by large populations from local fitness peaks is likely in nature.

@article{Weinreich2005RapidEE,
  title={Rapid evolutionary escape by large populations from local fitness peaks is likely in nature.},
  author={Daniel M. Weinreich and Lin Rui Chao},
  journal={Evolution; international journal of organic evolution},
  year={2005},
  volume={59 6},
  pages={1175-82}
}
Fitness interactions between loci in the genome, or epistasis, can result in mutations that are individually deleterious but jointly beneficial. Such epistasis gives rise to multiple peaks on the genotypic fitness landscape. The problem of evolutionary escape from such local peaks has been a central problem of evolutionary genetics for at least 75 years… CONTINUE READING