Rapid evaluation of the efficacy of pharmacologic agents and their analogs in enhancing bladder capacity and reducing the voiding frequency.

@article{Harada1992RapidEO,
  title={Rapid evaluation of the efficacy of pharmacologic agents and their analogs in enhancing bladder capacity and reducing the voiding frequency.},
  author={Toshiyuki Harada and P Levounis and Chritos E Constantinou},
  journal={Journal of pharmacological and toxicological methods},
  year={1992},
  volume={27 2},
  pages={119-26}
}
We report here the results of a simplified screening method to rapidly compare the pharmacologic action of drugs relevant to the urinary tract. This method avoids the use of anesthesia and of external infusion into the bladder relying on the physiological stimulation of the volume-evoked micturition reflex (VEMR) by diuresis. Mature female rats weighing 240… CONTINUE READING