Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

@inproceedings{Madroal2016RapidEO,
  title={Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells},
  author={Noelia Madro{\~n}al and Jos{\'e} Mar{\'i}a Delgado-Garc{\'i}a and Azahara Fern{\'a}ndez-Guiz{\'a}n and Jayanta Chatterjee and Maja K{\"o}hn and Camilla Mattucci and Apar Jain and Theodoros Tsetsenis and Anna Illarionova and Valery Grinevich and Cornelius Thilo Gross and Agn{\`e}s Gruart},
  booktitle={Nature communications},
  year={2016}
}
The hippocampus is critical for the acquisition and retrieval of episodic and contextual memories. Lesions of the dentate gyrus, a principal input of the hippocampus, block memory acquisition, but it remains unclear whether this region also plays a role in memory retrieval. Here we combine cell-type specific neural inhibition with electrophysiological measurements of learning-associated plasticity in behaving mice to demonstrate that dentate gyrus granule cells are not required for memory… CONTINUE READING
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