Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling


Previously, we found that rapid leukemia engraftment (short time to leukemia, TTLshort) in the NOD/SCID/huALL (non-obese diabetic/severe combined immuno-deficiency/human acute lymphoblastic leukemia) xenograft model is indicative of early patient relapse. As earlier intact apoptosis sensitivity was predictive for good prognosis in patients, we investigated… (More)
DOI: 10.1038/cddis.2012.107


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