Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

@inproceedings{Shi2016RapidEC,
  title={Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury},
  author={Yejie Shi and Lili Zhang and Hongjian Pu and Leilei Mao and Xiaoming Hu and Xiaoyan Jiang and Na Xu and Ruth Anne Stetler and Feng Zhang and Xiangrong Liu and Rehana K Leak and Richard F. Keep and Xunming Ji and Jun Chen},
  booktitle={Nature communications},
  year={2016}
}
The mechanism and long-term consequences of early blood-brain barrier (BBB) disruption after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover that I/R induces subtle BBB leakage within 30-60 min, likely independent of gelatinase B/MMP-9 activities. The early BBB disruption is caused by the activation of ROCK/MLC signalling, persistent actin polymerization and the disassembly of junctional proteins within microvascular endothelial cells (ECs). Furthermore, the… CONTINUE READING
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