Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 region.

@article{Haberman2008RapidEO,
  title={Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 region.},
  author={Rebecca P. Haberman and Hongjoo J. Lee and Carlo Colantuoni and Ming Teng Koh and Michela Gallagher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 30},
  pages={10601-6}
}
A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a spatial learning protocol to engage a pattern separation function to encode new information. After background training, two groups of animals experienced the same new training in a novel environment… CONTINUE READING
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