Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses.

@article{Morita2002RapidEO,
  title={Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses.},
  author={Keisuke Morita and Tetsuya Koga and Yoichi Moroi and Kazunori Urabe and Masutaka Furue},
  journal={The Journal of dermatology},
  year={2002},
  volume={29 11},
  pages={
          709-12
        }
}
Olopatadine hydrochloride is one of the second-generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis. We examined the inhibitory effects of this drug on the flare and wheal responses induced by histamine iontophoresis at 30, 60, and 90 min after oral administration in a double-blind, cross-over, and placebo-controlled study. Olopatadine hydrochloride significantly inhibited the histamine-induced flare and wheal… CONTINUE READING

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