Rapid early onset lymphocyte cell death in mice resistant, but not susceptible to Leishmania major infection

@article{Desbarats2000RapidEO,
  title={Rapid early onset lymphocyte cell death in mice resistant, but not susceptible to Leishmania major infection},
  author={Julie Desbarats and Jeffrey Stone and Lin Lin and Z Zakeri and Gerald S. Davis and Linda M. Pfeiffer and Richard G. Titus and M. Karen Newell},
  journal={Apoptosis},
  year={2000},
  volume={5},
  pages={189-196}
}
Leishmania major (Lm) infection in mice is a prototypical model for the role of immune deviation in disease resistance. Resistant strains of mice develop a Th1 response to Lm infection, distinguished by secretion of IL-12 and interferon γ. In contrast, susceptible strains display sustained IL-4 expression characteristic of a Th2 response. However, when mechanisms of cell death are blocked, mice display a susceptible phenotype even in the presence of a strong Th1 response, suggesting that cell… CONTINUE READING
7 Citations
48 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Cure of murine leishmaniasis with antiinterleukin 4 monoclonal antibody. Evidence for a T cell Apoptosis

  • MD Sadick, FP Heinzel, BJ Holaday, RT Pu, RS Dawkins, RM. Locksley
  • J Exp Med
  • 2000

Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major

  • H Louzir, PC Melby, A Ben Salah
  • J Infect Dis
  • 1998

Similar Papers

Loading similar papers…