Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hosts.

@article{Michael1997RapidDP,
  title={Rapid disease progression without seroconversion following primary human immunodeficiency virus type 1 infection--evidence for highly susceptible human hosts.},
  author={Nelson L Michael and Arthur E. Brown and Richard F Voigt and Sarah Schlesinger Frankel and John R. Mascola and Kyle Brothers and Mark Louder and Deborah L. Birx and S. Cassol},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={175 6},
  pages={1352-9}
}
A patient is described who rapidly progressed from primary human immunodeficiency virus (HIV) type 1 infection to death without seroconversion but with consistently high plasma viremia. His asymptomatic sex partner had been HIV-1 seropositive for >8 years prior to transmission. Analysis of viral sequences from these subjects and controls confirmed the transmission event. Although the biologic properties of the patient's virus were unremarkable, he had poor functional immune responses to HIV and… CONTINUE READING
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