Rapid direct detection of multiple rifampin and isoniazid resistance mutations in Mycobacterium tuberculosis in respiratory samples by real-time PCR.

@article{Marn2004RapidDD,
  title={Rapid direct detection of multiple rifampin and isoniazid resistance mutations in Mycobacterium tuberculosis in respiratory samples by real-time PCR.},
  author={Mercedes Mar{\'i}n and Dar{\'i}o Garc{\'i}a de Viedma and Mar{\'i}a Jes{\'u}s Ru{\'i}z-Serrano and Emilio Bouza},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 11},
  pages={4293-300}
}
Rapid detection of resistance in Mycobacterium tuberculosis can optimize the efficacy of antituberculous therapy and control the transmission of resistant M. tuberculosis strains. Real-time PCR has minimized the time required to obtain the susceptibility pattern of M. tuberculosis strains, but little effort has been made to adapt this rapid technique to the direct detection of resistance from clinical samples. In this study, we adapted and evaluated a real-time PCR design for direct detection… CONTINUE READING

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