Rapid diagnosis of tuberculosis through the detection of mycobacterial DNA in urine by nucleic acid amplification methods.

@article{Green2009RapidDO,
  title={Rapid diagnosis of tuberculosis through the detection of mycobacterial DNA in urine by nucleic acid amplification methods.},
  author={Cristina Green and Jim F Huggett and Elizabeth Talbot and Peter B Mwaba and Klaus Reither and Alimuddin Ismail Zumla},
  journal={The Lancet. Infectious diseases},
  year={2009},
  volume={9 8},
  pages={
          505-11
        }
}
Tuberculosis kills over 1.7 million people worldwide every year and nearly 40% of patients with active tuberculosis remain undiagnosed because of the poor sensitivity of the current, century old diagnostic method: sputum microscopy. Sputum microscopy is not able to easily detect paediatric, extrapulmonary, or HIV-associated tuberculosis, which are now important causes of morbidity and mortality in developing countries. Newer diagnostic methods for tuberculosis remain less sensitive than sputum… CONTINUE READING
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