Rapid diagnosis of pleural tuberculosis by polymerase chain reaction.

  title={Rapid diagnosis of pleural tuberculosis by polymerase chain reaction.},
  author={Julio Querol and Jos{\'e} Ram{\'o}n L{\'o}pez M{\'i}nguez and Enrique Garc{\'i}a-S{\'a}nchez and M. A. Farga and Concepci{\'o}n Gimeno and J Garc{\'i}a-de-lomas},
  journal={American journal of respiratory and critical care medicine},
  volume={152 6 Pt 1},
We have investigated the use of polymerase chain reaction (PCR) for the rapid diagnosis of pleural tuberculosis. The study was composed of 21 patients with pleural tuberculosis, confirmed by culture or pleural biopsy, and 86 control subjects. The PCR assay was based on detecting a 123-bp DNA segment belonging to the insertion sequence IS6110, specific of Mycobacterium tuberculosis complex. In 21 patients diagnosed with pleural tuberculosis, Ziehl-Neelsen staining was positive in three (14%) (95… CONTINUE READING


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