Rapid development of tolerance to sub-anaesthetic dose of ketamine: an oculomotor study in macaque monkeys

@article{Pouget2010RapidDO,
  title={Rapid development of tolerance to sub-anaesthetic dose of ketamine: an oculomotor study in macaque monkeys},
  author={Pierre Pouget and Nicolas Wattiez and Sophie Rivaud-Pechoux and Bertrand Gaymard},
  journal={Psychopharmacology},
  year={2010},
  volume={209},
  pages={313-318}
}
Ketamine, a non-competitive N-methyl-d-aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophrenia and has also been responsible for its illegal use as a recreational drug. Whereas the former has provided invaluable information, the latter has demonstrated that repeated administration… CONTINUE READING

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