Rapid determination of trisomy 21 from amniotic fluid cells using single-nucleotide polymorphic loci.

@article{Nagy2005RapidDO,
  title={Rapid determination of trisomy 21 from amniotic fluid cells using single-nucleotide polymorphic loci.},
  author={B{\'a}lint Nagy and Zolt{\'a}n B{\'a}n and Levente L{\'a}z{\'a}r and Rich{\'a}rd Gyula Nagy and Csaba Papp and Ernō T{\'o}th-P{\'a}l and Zolt{\'a}n Papp},
  journal={Prenatal diagnosis},
  year={2005},
  volume={25 12},
  pages={1138-41}
}
OBJECTIVES Rapid detection of trisomy 21 is an important goal for prenatal genetic centers. Fluorescent-PCR and DNA fragment analysis was developed a decade ago and thousands of samples were analyzed in routine practice using this method. Quantitative real-time PCR with melting curve analysis using SNP markers for trisomy 21 detection was described recently… CONTINUE READING