Rapid detection of the SPINK5 polymorphism Glu420Lys by real-time PCR technology.

BACKGROUND The SPINK5 gene, encoding the serine protease inhibitor LEKTI maps to chromosome 5q32, and has been suggested to be a locus predisposing to atopic diseases in general. The Glu420Lys variant showed significant association with atopy, asthma and atopic dermatitis in recent studies. AIMS OF THE STUDY Development of a high throughput assay to… CONTINUE READING