Rapid detection of the "highly virulent" group B Streptococcus ST-17 clone.

  title={Rapid detection of the "highly virulent" group B Streptococcus ST-17 clone.},
  author={Marie-C{\'e}cile Lamy and Shaynoor Dramsi and Annick Bill{\"o}et and H{\'e}l{\`e}ne R{\'e}glier-Poupet and Asmaa Tazi and Josette Raymond and François Gu{\'e}rin and Elisabeth Couv{\'e} and Frank Kunst and Philippe Glaser and Patrick Trieu-Cuot and Claire Poyart},
  journal={Microbes and infection},
  volume={8 7},
Group B streptococcus (GBS) is a leading cause of neonatal morbidity and mortality. Multilocus sequence typing (MLST) revealed that the sequence type ST-17 defines a "highly virulent" serotype III clone strongly associated with neonatal invasive infections. Our aim was to identify a target sequence enabling rapid, simple, and specific detection of this clone by a real-time PCR assay. Conventional methods for DNA manipulation and gene analyses were used to characterize the gbs2018 gene variant… CONTINUE READING