Rapid detection of rpoB gene mutations conferring rifampin resistance in Mycobacterium tuberculosis.

  title={Rapid detection of rpoB gene mutations conferring rifampin resistance in Mycobacterium tuberculosis.},
  author={Wanyuan Ao and Stephen Aldous and Evelyn S Woodruff and Brian J Hicke and Larry Rea and Barry Kreiswirth and Robert Jenison},
  journal={Journal of clinical microbiology},
  volume={50 7},
Multidrug-resistant Mycobacterium tuberculosis strains are widespread and present a challenge to effective treatment of this infection. The need for a low-cost and rapid detection method for clinically relevant mutations in Mycobacterium tuberculosis that confer multidrug resistance is urgent, particularly for developing countries. We report here a novel test that detects the majority of clinically relevant mutations in the beta subunit of the RNA polymerase (rpoB) gene that confer resistance… CONTINUE READING
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