Rapid detection of methylation change at H19 in human imprinting disorders using methylation-sensitive high-resolution melting.

Abstract

Beckwith Wiedemann syndrome (BWS) and Russell Silver syndrome (RS) are growth disorders with opposing epimutations affecting the H19/IGF2 imprinting center at 11p15.5. Overgrowth and tumor risk in BWS is caused by aberrant expression of the paternally expressed, imprinted IGF2 gene, occurring as a consequence of mosaic hypermethylation within the imprinting… (More)
DOI: 10.1002/humu.20779

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@article{Wojdacz2008RapidDO, title={Rapid detection of methylation change at H19 in human imprinting disorders using methylation-sensitive high-resolution melting.}, author={Tomasz K. Wojdacz and Alexander Dobrovic and Elizabeth M. Algar}, journal={Human mutation}, year={2008}, volume={29 10}, pages={1255-60} }