Corpus ID: 34383807

Rapid detection of factor V Leiden (FVQ506) by non-radioactive single strand conformation polymorphism (SSCP).

@article{Arruda1996RapidDO,
  title={Rapid detection of factor V Leiden (FVQ506) by non-radioactive single strand conformation polymorphism (SSCP).},
  author={V. Arruda and P. M. von Zuben and J. Annichino-Bizzachi and F. Costa},
  journal={Sangre},
  year={1996},
  volume={41 5},
  pages={
          379-81
        }
}
  • V. Arruda, P. M. von Zuben, +1 author F. Costa
  • Published 1996
  • Chemistry, Medicine
  • Sangre
  • The transition G-->A at position 506 of the factor V gene is responsible for resistance to the anticoagulant effect of activated protein C (APC-resistance), and represents the most common hereditary risk factor for venous thrombosis. A comparison of the ability of non-radioactive single-strand conformation polymorphism (SSCP) and of a standard PCR procedure followed by further digestion with MnlI to detect this factor V gene (FVQ 506) transition indicates that these is a good agreement between… CONTINUE READING
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