Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LC-MS/MS.

@article{Peaper2013RapidDO,
  title={Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LC-MS/MS.},
  author={David R. Peaper and Mandar V Kulkarni and Alexandra N Tichy and Michael A. Jarvis and Thomas S Murray and Michael E. Hodsdon},
  journal={Bioanalysis},
  year={2013},
  volume={5 2},
  pages={147-57}
}
BACKGROUND Bacteria are increasingly resistant to antibiotics used to treat life-threatening infections in critically ill patients. The carbapenems represent the last line of defense against Gram-negative rods that are increasingly resistant to all other classes of β-lactam antibiotics used to treat life-threatening infections in critically ill patients. Carbapenem resistance in Gram-negative rods is most commonly caused by expression of carbapenemases, enzymes that hydrolyze the β-lactam ring… CONTINUE READING
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