Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis.

@article{Khodoun2013RapidDO,
  title={Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis.},
  author={Marat V. Khodoun and Zeynep Yesim Kucuk and Richard T. Strait and Durga Krishnamurthy and Kevin C Janek and Corey D. Clay and Suzanne C. Morris and Fred D. Finkelman},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={132 6},
  pages={1375-87}
}
BACKGROUND Stimulatory IgG receptors (FcγRs) on bone marrow-derived cells contribute to the pathogenesis of several autoimmune and inflammatory disorders. Monoclonal antibodies that block FcγRs might suppress these diseases, but they can induce anaphylaxis. OBJECTIVE We wanted to determine whether a rapid desensitization approach can safely suppress IgG… CONTINUE READING