Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.

@article{Lu2014RapidDO,
  title={Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.},
  author={Aiping Lu and Minakshi Poddar and Ying Tang and Jonathan D. Proto and Jihee Sohn and Xiaodong Mu and Nicholas M. Oyster and Bing Wang and Johnny Huard},
  journal={Human molecular genetics},
  year={2014},
  volume={23 18},
  pages={4786-800}
}
Duchenne muscular dystrophy (DMD) patients lack dystrophin from birth; however, muscle weakness becomes apparent only at 3-5 years of age, which happens to coincide with the depletion of the muscle progenitor cell (MPC) pools. Indeed, MPCs isolated from older DMD patients demonstrate impairments in myogenic potential. To determine whether the progression of… CONTINUE READING