Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impact

@article{Samaha2005RapidDO,
  title={Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impact},
  author={Anne-No{\"e}l Samaha and Wai-Ying Wendy Yau and Pengwei Yang and Terry E. Robinson},
  journal={Biological Psychiatry},
  year={2005},
  volume={57},
  pages={351-360}
}
BACKGROUND Nicotine is highly addictive when it is inhaled from tobacco smoke, whereas nicotine replacement products, which usually deliver nicotine orally or transdermally, rarely lead to addiction. It has been proposed that this is due in part to differences in the rate of nicotine delivery to the brain under the two conditions. However, the mechanism by which rapid nicotine delivery facilitates the transition to addiction is not known. The ability of drugs to alter gene regulation and to… CONTINUE READING

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