Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.

@article{Goulder2001RapidDO,
  title={Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.},
  author={Philip J. R. Goulder and Marylyn Martina Addo and Marcus Altfeld and E. S. Rosenberg and Yanhua Tang and Umeshree Govender and Nolwandle Mngqundaniso and Ken Annamalai and Thorsten U. Vogel and Michael Hammond and Mike Bunce and Hoosen Mahomed Coovadia and Bruce D. Walker},
  journal={Journal of virology},
  year={2001},
  volume={75 3},
  pages={1339-47}
}
Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) play a major role in control of viral replication. To understand the contribution of this antiviral response, an initial step is to fully define the specific epitopes targeted by CTL. These studies focused on CTL responses restricted by HLA-A*3002, one of the HLA-A molecules most prominent in African populations. To avoid the time-consuming effort and expense involved in culturing CTL prior to defining epitopes and… CONTINUE READING