Rapid decrease in ATP content without recovery phase during glutamate-induced cell death in cultured spinal neurons.


Glutamate neurotoxicity in the cultured neurons from rat spinal cord was evaluated on the basis of endogenous ATP content in the cells. A short exposure of the neurons to glutamate induced an immediate and rapid decrease in ATP content. Then, after removal of glutamate, no recovery of ATP content was observed for 24 h, eventually resulting in neuronal death… (More)