Rapid cytopathic effects of Clostridium perfringens beta-toxin on porcine endothelial cells.

@article{Gurtner2010RapidCE,
  title={Rapid cytopathic effects of Clostridium perfringens beta-toxin on porcine endothelial cells.},
  author={Corinne Gurtner and Francesca Popescu and Marianne Wyder and Esther Sutter and Friederike Zeeh and Joachim Frey and Conrad von Schubert and Horst Posthaus},
  journal={Infection and immunity},
  year={2010},
  volume={78 7},
  pages={2966-73}
}
Clostridium perfringens type C isolates cause fatal, segmental necro-hemorrhagic enteritis in animals and humans. Typically, acute intestinal lesions result from extensive mucosal necrosis and hemorrhage in the proximal jejunum. These lesions are frequently accompanied by microvascular thrombosis in affected intestinal segments. In previous studies we demonstrated that there is endothelial localization of C. perfringens type C beta-toxin (CPB) in acute lesions of necrotizing enteritis. This led… CONTINUE READING

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