Rapid cycling bipolar affective disorder. I. Association with grade I hypothyroidism.

  title={Rapid cycling bipolar affective disorder. I. Association with grade I hypothyroidism.},
  author={Mark S. Bauer and Peter C. Whybrow and Andrew Winokur},
  journal={Archives of general psychiatry},
  volume={47 5},
Thirty patients with rapid cycling bipolar affective disorder were studied prospectively to assess presence and severity of thyroid hypofunction. Seven (23%) were classified as having grade I hypothyroidism, while 8 (27%) had grade II and 3 (10%) had grade III abnormalities. This prevalence of grade I hypothyroidism is significantly greater than that reported in studies of unselected bipolar patients during long-term treatment with lithium carbonate, although only 63% of this sample of rapid… CONTINUE READING

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