Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase.

@article{Zhu2001RapidCO,
  title={Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase.},
  author={Bao Ting Zhu and U. K. Patel and May Xiaoxin Cai and Anthony J. T. Lee and Allan H. Conney},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2001},
  volume={31 12},
  pages={
          879-90
        }
}
1. The metabolic O-methylation of several catechol-containing tea polyphenols by rat liver cytosolic catechol-O-methyltransferase (COMT) has been studied. 2. When (-)-epicatechin was used as substrate, its O-merthylation showed dependence on incubation time, cytosolic protein concentration, incubation pH and concentration of S-adenosyl-L-methionine. The O-methylation of increasing concentrations of (-)-epicatechin followed typical Michaelis-Menten kinetics, and the apparent Km and Vmax were 51… CONTINUE READING

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