Rapid conversion of high into low striatal D2-dopamine receptor agonist binding states after an acute physiological dose of 17 beta-estradiol.

Abstract

Ovariectomized female rats injected with 17 beta-estradiol (100 ng, s.c.) showed, as previously observed, an increase of the dopamine (DA) metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) with no change of DA concentrations in the striatum. This increase was observed as soon as 15 min following the injection while plasma estradiol… (More)

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