Rapid communication: Inhibition of adenosine deaminase by azapurine ribonucleosides

@article{Shewach1992RapidCI,
  title={Rapid communication: Inhibition of adenosine deaminase by azapurine ribonucleosides},
  author={D. Shewach and S. Krawczyk and O. Acevedo and L. Townsend},
  journal={Biochemical Pharmacology},
  year={1992},
  volume={44},
  pages={1697-1700}
}
We have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but did not lower the Ki value for coformycin. Evaluation of these compounds in a MOLT-4 growth assay revealed that 2-azacoformycin was as effective as 2'-deoxycoformycin in potentiating growth inhibition by 2'-deoxyadenosine. The azapurine nucleosides merit further study as antitumor agents. 
The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase.
Matching active site and substrate structures for an RNA editing reaction.
Adenosine receptors and their modulators.
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