Rapid colorimetric assay for acetaminophen without salicylate or phenylephrine interference.

@article{Swanson1982RapidCA,
  title={Rapid colorimetric assay for acetaminophen without salicylate or phenylephrine interference.},
  author={Marianne Swanson and M I Walters},
  journal={Clinical chemistry},
  year={1982},
  volume={28 5},
  pages={1171-3}
}
A simple rapid, and economical procedure is presented for the quantitative determination of acetaminophen in serum. Acetaminophen is extracted into solvent, and, when back-extracted into base, is simultaneously reacted with Folin-Ciocalteau reagent to form a colored complex. The potential interference of bilirubin is eliminated by treatment with p-diazobenzene sulfonic acid. Results obtained with this method agree with those obtained by "high-pressure" liquid chromatography. 
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