Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation.

@article{Clark2006RapidCO,
  title={Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation.},
  author={Anna K Clark and Fulvio D'Aquisto and Clive Gentry and Fabien Marchand and Stephen B. McMahon and Marzia Malcangio},
  journal={Journal of neurochemistry},
  year={2006},
  volume={99 3},
  pages={868-80}
}
Mounting evidence supports the hypothesis that pro-inflammatory cytokines secreted by astrocytes and microglia modulate nociceptive function in the injured CNS and following peripheral nerve damage. Here we examine the involvement of interleukin-1beta (IL-1beta) and microglia activation in nociceptive processing in rat models of spinal cord inflammation. Following application of lipopolysaccharide (LPS) to an ex vivo dorsal horn slice preparation, we observed rapid secretion of IL-1beta which… CONTINUE READING
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