Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: A case–control study

@article{Ronaldson2012RapidCD,
  title={Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: A case–control study},
  author={Kathlyn J Ronaldson and Paul B. Fitzgerald and Andrew J. Taylor and Duncan J Topliss and John J McNeil},
  journal={Schizophrenia Research},
  year={2012},
  volume={141},
  pages={173-178}
}
BACKGROUND Despite the implementation of cardiac monitoring guidelines, clozapine-induced myocarditis continues to cause deaths in Australia, and the risk is a barrier to prescription of this effective drug for the treatment of schizophrenia. This study was designed to identify clinical and phenotypic risk factors for clozapine-induced myocarditis. METHOD Possible cases of clozapine related myocarditis occurring between June 1993 and November 2009 and a comparative group of controls taking… CONTINUE READING

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