Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.

@article{Krishnan2007RapidCE,
  title={Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.},
  author={Lakshmi Krishnan and Komal Gurnani and Chantal J. Dicaire and Henk van Faassen and Ahmed A. Zafer and Carsten J Kirschning and Subash Sad and G. Dennis Sprott},
  journal={Journal of immunology},
  year={2007},
  volume={178 4},
  pages={2396-406}
}
Vaccines capable of eliciting long-term T cell immunity are required for combating many diseases. Live vectors can be unsafe whereas subunit vaccines often lack potency. We previously reported induction of CD8(+) T cells to Ag entrapped in archaeal glycerolipid vesicles (archaeosomes). In this study, we evaluated the priming, phenotype, and functionality of the CD8(+) T cells induced after immunization of mice with OVA-Methanobrevibacter smithii archaeosomes (MS-OVA). A single injection of MS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses

Journal of biomedicine & biotechnology • 2010
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…